The Treaty of Versailles ended World War I, and formed the League of Nations to stop another War from happening.  But America was highly isolationist.  Wilson wanted us to be the savior of the world, while Americans wanted to go home and forget about the world.  Citing concerns of entangling alliances, the Senate voted the entire treaty down.  This ironically meant that America was still in a legal State of War, until separate peace treaties were finalized in 1921.